1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone

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1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone Suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone Basic information
Product Name:1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone
Synonyms:1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone;WX8
CAS:232935-92-1
MF:C22H22N8O
MW:414.46
EINECS:
Product Categories:
Mol File:232935-92-1.mol
1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone Structure
1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone Chemical Properties
Boiling point 706.4±70.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
pka15.66±0.30(Predicted)
form powder
color white to beige
InChIKeyNJIKLALXAPYTCW-BUVRLJJBSA-N
SMILESC1(NC2=CC=CC=C2)=NC(N/N=C/C3=CNC4=C3C=CC=C4)=NC(N5CCOCC5)=N1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone Usage And Synthesis
UsesWX8 (Ro 91-4714) is an ATP-competitive PIKFYVE inhibitor, with Kd values of 0.9 nM and 340 nM for PIKFYVE and PIP4K2C, respectively. WX8 (Ro 91-4714) inhibits lysosomal fission without effecting homotypic lysosomal fusion. WX8 (Ro 91-4714) is used in the research of autophagy-dependent cancer[1].
Biological ActivityWX8 (Ro 91-4714) is a selective phosphoinositide kinase PIKfyve inhibitor th at disrupts lysosome fission via tubulation, lysosomal trafficking, and heterotypic lysosomes-autophagosomes fusion (0.1-1 μM; U2OS), but not homotypic lysosome fusion. WX8 exhibits cancer-selective antiproliferation activity (IC50 = 48 nM/A375, 200 nM/U2OS; IC50 >10 μM/non-cancer 293T & HFF) with a higher potency than the PIKfyve inhibitor YM201636, or the lysosomal inhibitors chloroquine & hydroxychloroquine (A375 IC50 = 119 nM, 1.7 μM, 1.9 μM, repectively).
References[1] Ajit Roy, et al. Selective Termination of Autophagy-Dependent Cancers. Cells. 2024 Jun 25;13(13):1096. DOI:10.3390/cells13131096
[2] Gaurav Sharma, et al. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy. 2019 Oct;15(10):1694-1718. DOI:10.1080/15548627.2019.1586257
1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone Preparation Products And Raw materials
Tag:1H-Indole-3-carboxaldehyde, 2-[4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone(232935-92-1) Related Product Information
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