| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
DC Chemicals |
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021-58447131 13564518121 |
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doncunbiosci@gmail.com |
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| | 2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Basic information |
| | 2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Chemical Properties |
| density | 1.58±0.1 g/cm3(Predicted) | | pka | 12.33±0.60(Predicted) |
| | 2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Usage And Synthesis |
| Uses | GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma[1][2]. | | IC 50 | TRPA1 | | References | [1] Estrada A, et al. 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists. WO2016128529 A1.
[2] Balestrini A, et.al A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment. J Exp Med. 2021 Apr 5;218(4):e20201637. DOI:10.1084/jem.20201637 |
| | 2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Preparation Products And Raw materials |
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