2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1)

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2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) Suppliers list
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2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) Basic information
Product Name:2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1)
Synonyms:2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1);Lenalidomide-C5-NH2 (TFA)
CAS:2550398-71-3
MF:C20H24F3N3O5
MW:443.42
EINECS:
Product Categories:
Mol File:2550398-71-3.mol
2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) Structure
2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) Chemical Properties
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) Usage And Synthesis
UsesLenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].
IC 50Cereblon
References[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] Li Y, Yang J, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019;62(2):448-466. DOI:10.1021/acs.jmedchem.8b00909
2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1) Preparation Products And Raw materials
Tag:2,6-Piperidinedione, 3-[4-(5-aminopentyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, 2,2,2-trifluoroacetate (1:1)(2550398-71-3) Related Product Information
3-(4-(5-Aminopentyl)-1-oxoisoindolin-2-yl) piperidine-2,6-dione hydrochloride 2435715-90-3 3-(4-(4-Aminobutyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2,2,2-trifluoroacetate 3-(4-(3-Aminopropyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2,2,2-trifluoroacetate E3 Ligand-Linker Conjugate 4 1H-Isoindole-4-undecanoic acid, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-