- Ponazuril
-
- $0.00 / 25Kg/Drum
-
2026-03-05
- CAS:69004-04-2
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 1000kg
- Ponazuril
-
- $0.00 / 1kg
-
2026-03-05
- CAS:69004-04-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: Customise
|
| | Ponazuril Basic information |
| Product Name: | Ponazuril | | Synonyms: | Toltrazuril sulfone
Ponazuril;1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;ToltrazurilSulfone;1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione;Ponazuril [inn];Unii-jpw84as66u;1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione | | CAS: | 69004-04-2 | | MF: | C18H14F3N3O6S | | MW: | 457.38 | | EINECS: | 629-740-8 | | Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 69004-04-2.mol |  |
| | Ponazuril Chemical Properties |
| Melting point | 242° | | density | 1.507±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 6.46±0.20(Predicted) | | color | White to Off-White | | Major Application | forensics and toxicology
pharmaceutical (small molecule)
veterinary | | InChI | InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26) | | InChIKey | VBUNOIXRZNJNAD-UHFFFAOYSA-N | | SMILES | N1(C)C(=O)NC(=O)N(C2=CC=C(OC3=CC=C(S(C(F)(F)F)(=O)=O)C=C3)C(C)=C2)C1=O | | CAS DataBase Reference | 69004-04-2 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Ponazuril Usage And Synthesis |
| Description | Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses. | | Uses | Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM). | | Veterinary Drugs and Treatments | Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis
(EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum
and Toxoplasma infections in dogs or cats. | | in vivo | Toltrazuril sulfone (10-20 mg/kg; p.o.; daily; for 10 days) is effective in preventing and treating toxoplasmosis in mice[2].
| Animal Model: | Female CD-1 mice[2] | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Oral administration, daily, for 10 days | | Result: | Prevented and protected mice from toxoplasmosis. |
| | IC 50 | Coccidia | | References | [1] ETIENNE BENOIT. Stereoselective S-oxygenation of an aryl-trifluoromethyl sulfoxide to the corresponding sulfone by rat liver cytochromes P450[J]. Biochemical pharmacology, 1993, 46 12: Pages 2337-2341. DOI: 10.1016/0006-2952(93)90626-8
[2] SHEILA M MITCHELL. Efficacy of ponazuril in vitro and in preventing and treating Toxoplasma gondii infections in mice.[J]. Journal of Parasitology, 2004, 90 3: 639-642. DOI: 10.1645/ge-250r |
| | Ponazuril Preparation Products And Raw materials |
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