| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:PD-1/PD-L1-IN-14
CAS:2499965-12-5
Purity:95.00% Package:2mg;25mg;50mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PD-1/PD-L1-IN-14
CAS:2499965-12-5
Package:2mg/RMB 3170;25mg/RMB 10600;50mg/RMB 13800
|
Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- manufacturers
- PD-1/PD-L1-IN-14
-
- $1520.00 / 25mg
-
2025-07-29
- CAS:2499965-12-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- Basic information |
| | Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- Chemical Properties |
| Boiling point | 620.1±65.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | pka | 14.75±0.10(Predicted) | | form | Solid | | color | Light brown to brown |
| | Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- Usage And Synthesis |
| Uses | PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1]. | | References | [1] Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65(5):3879-3893. DOI:10.1021/acs.jmedchem.1c01682 |
| | Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- Preparation Products And Raw materials |
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