| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:RO5488608
CAS:1337920-46-3
Package:25mg/RMB 10600
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| | RO-5488608 Basic information |
| Product Name: | RO-5488608 | | Synonyms: | RO 5488608;RO5488608;RO-5488608;[1,1'-Biphenyl]-3-sulfonic acid, 3'-[2,3-dihydro-7-methyl-2-oxo-8-(trifluoromethyl)-1H-1,5-benzodiazepin-4-yl]- | | CAS: | 1337920-46-3 | | MF: | C23H17F3N2O4S | | MW: | 474.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1337920-46-3.mol |  |
| | RO-5488608 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | pka | -0.72±0.30(Predicted) |
| | RO-5488608 Usage And Synthesis |
| Description | RO5488608 is a new potent mGlu2/3 NAM. | | Uses | RO5488608 is a negative allosteric metabotropic modulator of glutamate receptor 2/3. RO5488608 inhibits LY354740 (HY-18941)-induced intracellular Ca2+ release and can be used for study of antidepressant[1]. | | References | [1] Lundstr?m L, et al. Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol. 2011;164(2b):521-537. DOI:10.1111/j.1476-5381.2011.01409.x |
| | RO-5488608 Preparation Products And Raw materials |
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