5-Iodoindirubin-3'-monoxime manufacturers
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| | 5-Iodoindirubin-3'-monoxime Basic information |
| Product Name: | 5-Iodoindirubin-3'-monoxime | | Synonyms: | 5-Iodoindirubin-3'-monoxime;2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-5-iodo-;Glycogen synthase kinase-3,GSK-3,5Iodoindirubin3'monoxime,CDK,Inhibitor,Glycogen synthase kinase 3,Cyclin dependent kinase,5 Iodo indirubin 3' monoxime,inhibit;5-Iodo-indirubin-3'-monoxime | | CAS: | 331467-03-9 | | MF: | C16H10IN3O2 | | MW: | 403.17 | | EINECS: | | | Product Categories: | | | Mol File: | 331467-03-9.mol |  |
| | 5-Iodoindirubin-3'-monoxime Chemical Properties |
| Boiling point | 583.3±50.0 °C(Predicted) | | density | 1.99±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 67.5 mg/mL (167.42 mM) | | pka | 8.52±0.20(Predicted) | | form | Solid | | color | Pink to red |
| | 5-Iodoindirubin-3'-monoxime Usage And Synthesis |
| Uses | 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1]. | | IC 50 | GSK-3β: 9 nM (IC50); Cdk5/p25: 20 nM (IC50); Cdk1/cyclin B: 25 nM (IC50) | | References | [1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200 |
| | 5-Iodoindirubin-3'-monoxime Preparation Products And Raw materials |
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