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Product Name:LMTK3 inibitor C28
CAS:2764850-23-7
Purity:>98% Remarks:Reach out to us for more information about custom solutions.
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LMTK3 inibitor C28 manufacturers
- LMTK3-IN-1
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- $48.00
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2026-05-06
- CAS:2764850-23-7
- Purity: 99.89%
- Supply Ability: 10g
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| | LMTK3 inibitor C28 Basic information |
| Product Name: | LMTK3 inibitor C28 | | Synonyms: | LMTK3 inibitor C28;LMTK3-IN-1;6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine;4-{3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl}pyridine | | CAS: | 2764850-23-7 | | MF: | C18H11F3N4O | | MW: | 356.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2764850-23-7.mol |  |
| | LMTK3 inibitor C28 Chemical Properties |
| storage temp. | -10 to -25°C | | solubility | Soluble to 50 mM in DMSO and to 20 mM in ethanol | | form | Solid | | color | Light yellow to yellow | | InChI | 1S/C18H11F3N4O/c19-18(20,21)26-14-3-1-2-13(10-14)16-11-23-17-5-4-15(24-25(16)17)12-6-8-22-9-7-12/h1-11H | | InChIKey | SFBZOJORTROAIE-UHFFFAOYSA-N | | SMILES | FC(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)(F)F |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | LMTK3 inibitor C28 Usage And Synthesis |
| Uses | LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM[1]. | | Biological Activity | C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα. | | storage | Store at -20°C | | References | [1] Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865. DOI:10.3390/ijms24010865 |
| | LMTK3 inibitor C28 Preparation Products And Raw materials |
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