- 4-Bromo-2-nitrobenzyl alcohol
-
- $100.00 / 1KG
-
2025-09-25
- CAS:22996-19-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | 4-Bromo-2-nitrobenzyl alcohol Basic information | | Uses |
| | 4-Bromo-2-nitrobenzyl alcohol Chemical Properties |
| Boiling point | 338.5±27.0 °C(Predicted) | | density | 1.767±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.57±0.10(Predicted) | | Appearance | Light yellow to light brown Solid |
| | 4-Bromo-2-nitrobenzyl alcohol Usage And Synthesis |
| Uses | 4-Bromo-2-nitrobenzyl alcohol is an alcoholic organic compound that can be used as an intermediate in organic synthesis. | | Synthesis | Step 1. A solution of borane tetrahydrofuran complex (1 M solution of tetrahydrofuran, 13 mL, 13 mmol) was slowly added dropwise to a tetrahydrofuran solution of 4-bromo-2-nitrobenzoic acid (2.00 g, 8.13 mmol) over 5 min at room temperature. Subsequently, the reaction mixture was heated to 72 °C and the reaction was stirred. Upon completion of the reaction, the mixture was carefully poured into saturated aqueous sodium bicarbonate solution to quench the reaction. The aqueous phase was extracted with ethyl acetate, the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the white solid product (4-bromo-2-nitrophenyl)methanol (1.85 g, 96% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 8.25 (d, J = 1.8Hz, 1H), 7.80 (dd, J = 8.1, 1.8Hz, 1H), 7.67 (d, J = 8.1Hz, 1H), 4.96 (d, J = 6.3Hz, 2H), 2.37 (t, J = 6.3Hz, 1H). | | References | [1] Patent: US2007/191603, 2007, A1. Location in patent: Page/Page column 40
[2] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 333
[3] MedChemComm, 2018, vol. 9, # 5, p. 862 - 869
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 18, p. 8402 - 8416 |
| | 4-Bromo-2-nitrobenzyl alcohol Preparation Products And Raw materials |
|