Benzamide, 4-(9-acridinylamino)-N-hydroxy-

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Benzamide, 4-(9-acridinylamino)-N-hydroxy- manufacturers

  • HDAC6-IN-6
  • HDAC6-IN-6 pictures
  • $1520.00
  • 2026-04-20
  • CAS:2413603-10-6
  • Purity:
  • Supply Ability: 10g
Benzamide, 4-(9-acridinylamino)-N-hydroxy- Basic information
Product Name:Benzamide, 4-(9-acridinylamino)-N-hydroxy-
Synonyms:Benzamide, 4-(9-acridinylamino)-N-hydroxy-;HDAC6-IN-6
CAS:2413603-10-6
MF:C20H15N3O2
MW:329.35
EINECS:
Product Categories:
Mol File:2413603-10-6.mol
Benzamide, 4-(9-acridinylamino)-N-hydroxy- Structure
Benzamide, 4-(9-acridinylamino)-N-hydroxy- Chemical Properties
density 1.382±0.06 g/cm3(Predicted)
pka9.06±0.10(Predicted)
Safety Information
MSDS Information
Benzamide, 4-(9-acridinylamino)-N-hydroxy- Usage And Synthesis
UsesHDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
IC 50HDAC6: 0.025 ± 0. μM (IC50); HDAC1: 0.34 ± 0.0 μM (IC50); HDAC: 0.55 ± 0.0 μM (IC50); HDAC9: 0.57 ± 0.0 μM (IC50); HDAC7: 0.65 ± 0.0 μM (IC50); HDAC5: 0.85 ± 0.0 μM (IC50); HDAC3: 1.22 ± 0.0 μM (IC50); HDAC2: 1.57 ± 0.0 μM (IC50); HDAC4: 2.24 ± 0.0 μM (IC50)
References[1] Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193. DOI:10.1016/j.ejmech.2020.112193
Benzamide, 4-(9-acridinylamino)-N-hydroxy- Preparation Products And Raw materials
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