| Company Name: |
Shanghai Easy CDMO Co.,Ltd
|
| Tel: |
021-61734564 13854185395; |
| Email: |
info@easycdmo.com |
| Products Intro: |
Product Name:Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)-
CAS:1809420-71-0
Purity:98% Package:10mg;1g;10g;100g;1kg
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Resomelagon
CAS:1809420-71-0
Purity:95% Package:2mg;5mg;25mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Resomelagon
CAS:1809420-71-0
Package:2mg/RMB 1270;5mg/RMB 2350;25mg/RMB 8160
|
Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)- manufacturers
- Resomelagon
-
- $1740.00 / 100mg
-
2025-04-29
- CAS:1809420-71-0
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)- Basic information |
| | Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)- Chemical Properties |
| Boiling point | 513.0±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 8.85±0.70(Predicted) | | form | Solid | | color | Light brown to brown |
| | Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)- Usage And Synthesis |
| Uses | Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research[1][2]. | | in vivo | Resomelagon (0-10 mg/kg; i.p., i.v. and p.o.; for 24 h; male C57BL/6J wild-type (WT) and BALB/c mice) promotes resolution of acute inflammation in vivo[1].
Resomelagon (25-50 mg/kg; p.o.; daily, for 8 d; male C57BL/6J wild-type (WT) and BALB/c mice) reduces arthritis in mice[1]. | Animal Model: | Male C57BL/6J wild-type (WT) and BALB/c mice[1] | | Dosage: | 0, 0.1, 1 and 10 mg/kg | | Administration: | Oral administration, intraperitoneal injection and intravenous injection; for 24 hours | | Result: | Inhibited neutrophil and monocyte infiltration in a dose-dependent manner. |
| Animal Model: | Male C57BL/6J wild-type (WT) and BALB/c mice[1] | | Dosage: | 25 and 50 mg/kg | | Administration: | Oral administration; daily; for 8 days | | Result: | Reduced all signs of arthritis measured, including clinical score (-42%), paw swelling (-87%), proportion of animals with all four paws affected (-50%), and the severity of the inflammation (-70%). |
| | IC 50 | MC1R; MC3R | | References | [1] Montero-Melendez T, et, al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194(7):3381-8. DOI:10.4049/jimmunol.1402645
[2] WHO Drug Information. International Nonproprietary Names for Pharmaceutical |
| | Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)- Preparation Products And Raw materials |
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