(1E,13E) Tilmicosin-d3 manufacturers
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| | (1E,13E) Tilmicosin-d3 Basic information |
| | (1E,13E) Tilmicosin-d3 Chemical Properties |
| solubility | Chloroform: slightly soluble
Methanol: slightly soluble | | form | Solid | | color | White to off-white |
| | (1E,13E) Tilmicosin-d3 Usage And Synthesis |
| Uses | Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects[1][2]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Micotil 300 New Animal Drug Application
[3] NIELS MØLLER ANDERSEN. Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.[J]. Antimicrobial Agents and Chemotherapy, 2012: 6033-6036. DOI: 10.1128/aac.01250-12
[4] A. KART. The Possible Protective effect of L-carnitine on Tilmicosin-induced Cardiotoxicity in Mice[J]. Transboundary and Emerging Diseases, 2007, 54 3: 144-146. DOI: 10.1111/j.1439-0442.2007.00897.x |
| | (1E,13E) Tilmicosin-d3 Preparation Products And Raw materials |
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