- 2-Aminonicotinic acid
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- $0.00 / 1Kg/Bag
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2026-01-27
- CAS:5345-47-1
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 10 tons
- 2-Aminonicotinic acid
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- $100.00/ kg
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2026-01-21
- CAS:5345-47-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
- 2-Aminonicotinic acid
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- $1.00 / 1KG
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2026-01-05
- CAS:5345-47-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | 2-Aminonicotinic acid Basic information | | Structure |
| | 2-Aminonicotinic acid Chemical Properties |
| Melting point | 295-297 °C (dec.)(lit.) | | Boiling point | 253.51°C (rough estimate) | | density | 1.3471 (rough estimate) | | refractive index | 1.5100 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO | | pka | 2.94±0.10(Predicted) | | form | Crystalline Powder | | color | Off-white to light yellow | | Water Solubility | soluble | | BRN | 119031 | | InChI | InChI=1S/C6H6N2O2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H2,7,8)(H,9,10) | | InChIKey | KPIVDNYJNOPGBE-UHFFFAOYSA-N | | SMILES | C1(N)=NC=CC=C1C(O)=O | | CAS DataBase Reference | 5345-47-1(CAS DataBase Reference) | | EPA Substance Registry System | 2-Aminonicotinic acid (5345-47-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-37/39-26-36 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids |
| | 2-Aminonicotinic acid Usage And Synthesis |
| Structure | 2-aminonicotinic acid (or 2-aminopyridine-3-carboxylic acid, abbreviated ANA) can be a model compound for reactions containing carboxylic and amino groups attached to the pyridine ring. X-ray diffraction studies have shown that in the molecular crystal phase, ANA occurs as a zwitterion in which protonation occurs at the nitrogen atom of the pyridine ring. Infrared spectra of ANA molecular crystal have confirmed that intra- and intermolecular hydrogen bonds are present in its structure. Karabacak et al. investigated the tautomerism of ANA using electronic structure calculations (B3LYP/6-311++G(d,p)) and identified four amino tautomers. Furthermore, Nayak and Dogra optimized the structures of two amino and two imino structures at the B3LYP/6-31G** level. On the basis of both experimental data (absorption and fluorescence spectra) and electronic structure calculations, these authors concluded that ANA is present in solutions as the amino form in both the S0 and S1 states, whereas the imino forms are absent. ANA exists as a molecular species in non-polar and polar aprotic solvents and as a zwitterion in polar protic solvents[1]. | | Chemical Properties | Off-white to light yellow crystalline powder | | Uses | A component of hair dyes. | | Uses | 2-Aminopyridine-3-carboxylic acid can be used as:
- A ligand to prepare copper(II)-organic coordination compounds.
- A reactant to prepare pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolines by reacting with trimethylsilyl cyanide and phthalaldehyde.
- A reactant to synthesize organo-soluble and thermally stable poly(thiourea-amide-imide) polymers.
| | Definition | ChEBI: An aminonicotinic acid in which the amino group is situated at position 2 of the pyridine ring. | | Synthesis | Step 4. 30 mL of 5 mol-L?1 sodium hydroxide solution was added to a 100 mL flask and cooled to 5 °C. After cooling to 5 °C, 0.02 mol of bromine was added slowly and the reaction was stirred for 0.5 hours. Subsequently, 0.02 mol 2-aminopyridine-3-carboxylic acid was added and the temperature was raised to 85 °C and kept for 2 hours for the reaction. Step 5: After completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove some of the solvent. After cooling, the pH was adjusted to 7 with dilute hydrochloric acid and the precipitate was collected by filtration. The resulting solid was dried and evaporated to give final crystals of 2-aminopyridine-3-carboxylic acid as a white solid. | | References | [1] M. Pagacz-Kostrzewa . “Phototransformations of 2-aminonicotinic acid resolved with matrix isolation infrared spectroscopy and ab initio calculations.” Journal of Photochemistry and Photobiology A-chemistry 410 (2021): Article 113187.
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| | 2-Aminonicotinic acid Preparation Products And Raw materials |
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