2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)-

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2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)- manufacturers
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)- Basic information
Product Name:2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)-
Synonyms:2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)-;Nrf2 activator-5
CAS:1012860-13-7
MF:C25H30Cl2O6
MW:497.41
EINECS:
Product Categories:
Mol File:1012860-13-7.mol
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)- Structure
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)- Chemical Properties
Boiling point 688.8±55.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
pka6.14±0.70(Predicted)
Safety Information
MSDS Information
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)- Usage And Synthesis
UsesNrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities[1].
References[1] Choi JW, et, al. Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities. Bioorg Chem. 2020 Dec;105:104434. DOI:10.1016/j.bioorg.2020.104434
2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)- Preparation Products And Raw materials
Tag:2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4a-dichloro-3,4,4a,10a-tetrahydro-6,8-dihydroxy-10a-[(2E,6E)-8-hydroxy-3,7-dimethyl-2,6-octadien-1-yl]-2,2-dimethyl-, (3R,4aR,10aS)-(1012860-13-7) Related Product Information
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