Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]-

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Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:MAGLi 432
CAS:2361575-20-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: TargetMol Chemicals Inc.
Tel: 13564774135
Email: marketing@targetmol.com
Products Intro: Product Name:MAGLi 432
CAS:2361575-20-2
Package:100mg;3520USD|50mg;2785USD|25mg;2140USD
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com
Products Intro: Product Name:MAGLi 432
CAS:2361575-20-2
Package:1removed
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Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Products Intro: Product Name:MAGLi 432
CAS:2361575-20-2
Purity:98% Package:5mg;25mg;100mg;1g;5g

Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- manufacturers

  • MAGLi 432
  • MAGLi 432 pictures
  • $3520.00
  • 2026-05-11
  • CAS:2361575-20-2
  • Purity:
  • Supply Ability: 10g
Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- Basic information
Product Name:Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]-
Synonyms:Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]-;[(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-(2-bromo-3-methoxyphenyl)methanone
CAS:2361575-20-2
MF:C22H24BrClN2O2
MW:463.8
EINECS:
Product Categories:
Mol File:2361575-20-2.mol
Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- Structure
Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- Chemical Properties
Boiling point 589.6±50.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
pka8.43±0.40(Predicted)
Safety Information
MSDS Information
Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- Usage And Synthesis
UsesMAGLi 432 is a non-covalent, potent, highly selective, and reversible MAGL inhibitor. MAGLi 432 binds with high affinity to the MAGL active site, with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme). MAGLi 432 can be used in the research of chronic inflammation, blood–brain barrier dysfunction, neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease[1].
in vivo

MAGLi 432 (intraperitoneal injection, 1 mg/kg for 3 consecutive days) inhibits MAGL in the brain and reduces arachidonic acid and PGE2 levels in LPS-induced neuroinflammation, without reducing BBB permeability and inflammatory cytokine expression in the cortex[1].

Animal Model:Male CD-1 mice model of LPS-induced neuroinflammation[1]
Dosage:1 mg/kg for 3 consecutive days
Administration:Intraperitoneal injection
Result:Accumulated ~10-fold more 2-AG than vehicle controls, reducted LPS-induced PGE2.
Increased LCN2 and TNF expression compared to the LPS treatment.
References[1] Alicia Kemble, et al. A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. bioRxiv 2022.05.04.490688.
Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]- Preparation Products And Raw materials
Tag:Methanone, (2-bromo-3-methoxyphenyl)[(7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]-(2361575-20-2) Related Product Information
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