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Riedel-de Haen AG
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CAS:221368-54-3
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SIGMA-RBI
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800 736 3690 (Orders) |
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| | (5r,11r)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol Basic information |
| Product Name: | (5r,11r)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol | | Synonyms: | 2,8-Chrysenediol, 5,11-diethyl-5,6,11,12-tetrahydro-, (5R,11R)- | | CAS: | 221368-54-3 | | MF: | C22H24O2 | | MW: | 320.42 | | EINECS: | | | Product Categories: | | | Mol File: | 221368-54-3.mol |  |
| | (5r,11r)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol Chemical Properties |
| Melting point | 241-243 °C | | Boiling point | 519.0±50.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 10.27±0.60(Predicted) | | form | Solid | | color | Light yellow to brown |
| | (5r,11r)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol Usage And Synthesis |
| Uses | (R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1]. | | Definition | ChEBI: (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol is a carbotetracyclic compound that is 5,6,11,12-tetrahydrochrysene substituted by hydroxy groups at positions 2 and 8 and by ethyl groups at positions 5 and 11 (the 5R,11R-stereoisomer). It is an agonist of ER-alpha and antagonist of ER-beta receptors. It has a role as an estrogen receptor antagonist, an estrogen receptor agonist, a geroprotector and a neuroprotective agent. It is a carbotetracyclic compound and a polyphenol. | | IC 50 | ERα: 9.0 nM (Ki); ERβ: 3.6 nM (Ki) | | References | [1] Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804. DOI:10.1210/endo.140.2.6480 |
| | (5r,11r)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol Preparation Products And Raw materials |
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