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BI-0474

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Company Name: Hubei Chuchang Biotech Co., Ltd.
Tel: +undefined15623860702
Email: info@chuchangbiotech.com
Products Intro: Product Name:BI-0474
CAS:2750570-55-7
Purity:98%+ HPLC HNMR Package:10mg;0.00;USD|50mg;0.00;USD|100mg;0.00;USD
Company Name: Suzhou Ryan Pharmachem Technology Co.,Ltd.
Tel: +86-512-68780025
Email: sales@ryanchem.com
Products Intro: Product Name:Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
CAS:2750570-55-7
Purity:99% Package:G;KG;T
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:BI-0474
CAS:2750570-55-7
Purity:100% Package:1mg;388USD|5mg;818USD|10mg;1230USD
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel: +8613720134139
Email: orders@jknbiochem.com
Products Intro: Product Name:BI-0474
CAS:2750570-55-7
Purity:0.98 Package:10G:100G
Company Name: NANJING YINGWEN BIOTECHNOLOGY CO LTD
Tel: +8613382787392
Email: sales@aeechem.com
Products Intro: CAS:2750570-55-7
Purity:98%

BI-0474 manufacturers

  • BI-0474
  • BI-0474 pictures
  • $52.00 / 1mg
  • 2026-04-22
  • CAS:2750570-55-7
  • Min. Order:
  • Purity: 99.96%
  • Supply Ability: 10g
  • BI-0474
  • BI-0474 pictures
  • $0.00 / 10mg
  • 2025-03-16
  • CAS:2750570-55-7
  • Min. Order: 5mg
  • Purity: 98%+ HPLC HNMR
  • Supply Ability: 10g
BI-0474 Basic information
Product Name:BI-0474
Synonyms:Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-;BI-0474
CAS:2750570-55-7
MF:C30H37N9O2S
MW:587.74
EINECS:
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Mol File:2750570-55-7.mol
BI-0474 Structure
BI-0474 Chemical Properties
Boiling point 879.4±75.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
form Solid
pka7.13±0.70(Predicted)
color White to off-white
InChIKeyCKAMBYUZKWQCKJ-ADSBAMQRSA-N
SMILESC12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2
Safety Information
MSDS Information
BI-0474 Usage And Synthesis
DescriptionBI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM.
Uses BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
in vitroBI-0474 (1-10,000 nM; 3 days) shows potent antiproliferative activity of 26 nM on NCI-H358 cells carrying a G12C mutation.
in vivoBI-0474 (40 mg/kg; i.p.; single daily for 3 days) shows anti-tumor efficacy and pharmacodynamic biomarker modulation in an NCI-H358 cell line-derived non-small cell lung cancer xenograft model
IC 50KRAS-SOS1: 7.0 nM (IC50)
BI-0474 Preparation Products And Raw materials
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