- HATU
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- $0.00 / 1kg
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2026-01-23
- CAS:148893-10-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20MT
- HATU
-
- $0.00 / 1Kg/Bag
-
2026-01-23
- CAS:148893-10-1
- Min. Order: 1KG
- Purity: 99.5%min
- Supply Ability: 1000KGS
- HATU
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- $10.00 / 1KG
-
2026-01-05
- CAS:148893-10-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5tons
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| Product Name: | HATU | | Synonyms: | 2-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;HATU >=98.0% (CHN);1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, ChemDoseTM tablets;O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUORO-PHOSPHATE;O-(7-AZABENZOTRIAZOLE-1-YL)-N, N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPATE | | CAS: | 148893-10-1 | | MF: | C10H15F6N6OP | | MW: | 380.24 | | EINECS: | 604-662-7 | | Product Categories: | peptides;carboxylic ester;HATU;Peptide Coupling Reagents;Miscellaneous Reagents;Coupling Reagent;PROTECTED AMINO ACID & PEPTIDES;Pharmaceutical Intermediates;Amino Acid Derivatives;Peptide coupling agents;Peptide;intermediate;148893-10-1 | | Mol File: | 148893-10-1.mol |  |
| Melting point | 183-188 °C (dec.) | | RTECS | XZ5633000 | | storage temp. | 2-8°C | | solubility | >16mg/mL in DMSO | | form | powder to crystaline | | color | White to Almost white | | Water Solubility | Soluble in acetonitrile. Insoluble in water. | | Major Application | peptide synthesis | | InChI | InChI=1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1 | | InChIKey | KZAWCZZRROLLDL-UHFFFAOYSA-N | | SMILES | [P+5]([F-])([F-])([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=NC=CC=C/12)(\N(C)C)/N(C)C | | CAS DataBase Reference | 148893-10-1(CAS DataBase Reference) | | EPA Substance Registry System | 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide (148893-10-1) |
| Hazard Codes | Xi,Xn,E | | Risk Statements | 36/37/38-20/21/22-2 | | Safety Statements | 26-37/39-36/37-36-35 | | RIDADR | 1325 | | WGK Germany | 3 | | F | 10-21 | | HazardClass | 4.1 | | PackingGroup | Ⅱ | | HS Code | 29339999 | | Storage Class | 4.1A - Other explosive hazardous materials | | Hazard Classifications | Resp. Sens. 1
Skin Sens. 1A |
| Description | HATU, first prepared by Louis A. Carpino in 1993, is widely used in carboxylic acid amidation reactions. It acts as a facilitator of amide bond generation by activating the carboxyl group. | | Chemical Properties | White crystalline to off-white powder | | Uses | HATU[148893-10-1] is a coupling reagent and used as an additive in peptide synthesis. It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.
Reagent for: Synthesis of Aurora A kinase inhibitors, HPLC assay to determine D- and L- acid enantiomers in human plasma, Amide bond formation reactions.
Catalyst for: Selective acylation, Selecocyclization-oxidation deselenation sequence. | | Reactions | HATU is a very promising coupling agent for chemical protein synthesis.
This strategy was exploited to prepare macrocycles from the trimeric linear arylopeptoids (ortho-, meta-, and para-) containing isopropyl or ethyl side chains, synthesized as described by Hjelmgaard et al. The cyclization procedure reported for α,β-cyclopeptoids was applied. The linear arylopeptoids were cyclized in the presence of HATU and DIPEA in CH?Cl?/DMF (4:1) after the deprotection of the tert-butyl group in TFA/CH?Cl?.
After the synthesis of the Fmoc-protected monomers, the oligomers were synthesized on the 2-chlorotrityl resin with excellent yield of coupling (>98%). The trimers and tetramers of the different isomers were synthesized in good overall yield (60-84%). Then, the crude oligomers were cyclized in DMF in the presence of HATU and DIPEA in high dilution (3 × 10?3 M) to furnish the cyclized trimers and tetramers in good yields ranging between 32% and 72%. | | reaction suitability | reaction type: Coupling Reactions | | Synthesis | The synthesis of HATU is as follows:The resulting residue treated with 2-Methoxycarbonylamino-3-methyl-butyric acid (60 mg, 0.343 mmol) and HATU (130 mg, 0.343 mmol), suspended in DMF (3 mL) and cooled to 0° C. DIPEA (0.272 mL, 1.56 mmol) was added dropwise. After stirring for 4 h, NaOH (5M in H2O, 0.300 mL, 1.5 mmol) was added. This mixture was stirred for 3 h then diluted with EtOAc and washed with 1 M LiOH (2*) then brine. The organic phase was dried over MgSO4, filtered and concentrated. The crude residue was then purified by HPLC to afford the title compound (53 mg, 44%). 
| | References | [1] CHAWLA P A, SHOME A, JHA K T. Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium (HATU): A Unique Cross-Coupling Reagent[J]. SynOpen, 2023, 66 2: 0. DOI:10.1055/s-0042-1751499.
[2] LOUIS A. CARPINO. Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers?,?[J]. Organic Letters, 2000, 2 15: 2253-2256. DOI:10.1021/ol006013z. |
| | HATU Preparation Products And Raw materials |
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