5-PHENYL-2-FUROIC ACID manufacturers
- 5-PHENYL-2-FUROIC ACID
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- $15.00 / 1KG
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2021-08-11
- CAS:52938-97-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 5-PHENYL-2-FUROIC ACID Basic information |
| | 5-PHENYL-2-FUROIC ACID Chemical Properties |
| Melting point | 150-154 °C (lit.) | | Boiling point | 368.2±30.0 °C(Predicted) | | density | 1.254±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | powder to crystal | | pka | 3.15±0.10(Predicted) | | color | White to Light yellow | | InChI | 1S/C11H8O3/c12-11(13)10-7-6-9(14-10)8-4-2-1-3-5-8/h1-7H,(H,12,13) | | InChIKey | GUOMINFEASCICM-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccc(o1)-c2ccccc2 | | CAS DataBase Reference | 52938-97-3(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2932190090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-PHENYL-2-FUROIC ACID Usage And Synthesis |
| Synthesis | GENERAL METHODS: To a mixed solution of 5-(3-chlorophenyl)-2-furaldehyde (19a) (206 mg, 1.00 mmol) dissolved in tert-butanol (37.5 mL) and water (7.5 mL) was added sequentially NaH2PO4 (213 mg, 1.50 mmol), 2-methyl-2-butene (0.78 mL, 7.50 mmol) and NaClO2 (228 mg, 2.50 mmol). The reaction mixture was stirred at room temperature for 11 hours. After completion of the reaction, the volatile solvent was removed by distillation under reduced pressure and water and 1N hydrochloric acid were added. The mixture was extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give 5-phenyl-2-furoic acid (22a) (214 mg, 97% yield) as a white solid. | | References | [1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 21, p. 6384 - 6393,10
[2] Journal of Pharmaceutical Sciences, 1980, vol. 69, # 1, p. 107 - 110
[3] Patent: US2010/130556, 2010, A1. Location in patent: Page/Page column 25
[4] Bulletin of the Chemical Society of Japan, 1975, vol. 48, p. 491,494
[5] Heterocycles, 2014, vol. 89, # 2, p. 453 - 464 |
| | 5-PHENYL-2-FUROIC ACID Preparation Products And Raw materials |
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