Ro 16-6491 manufacturers
- Ro 16-6491
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- $2500.00
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2026-05-11
- CAS:87235-61-8
- Purity:
- Supply Ability: 10g
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| | Ro 16-6491 Basic information |
| Product Name: | Ro 16-6491 | | Synonyms: | Ro 166491,Ro 16 6491;Benzamide, N-(2-aminoethyl)-4-chloro-;RO 16-6491 Free base | | CAS: | 87235-61-8 | | MF: | C9H11ClN2O | | MW: | 198.65 | | EINECS: | | | Product Categories: | | | Mol File: | 87235-61-8.mol |  |
| | Ro 16-6491 Chemical Properties |
| Boiling point | 379.0±27.0 °C(Predicted) | | density | 1.226±0.06 g/cm3(Predicted) | | pka | 13.99±0.46(Predicted) |
| | Ro 16-6491 Usage And Synthesis |
| Description | Ro 16-6491 is a selective, reversible, orally-active MAO-B inhibitor. | | Uses | RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states. | | Definition | ChEBI: N-(2-aminoethyl)-4-chlorobenzamide is a carbonyl compound and an organohalogen compound. | | References | [1] Binding of [3H]Ro 16-6491, a reversible inhibitor of monoamine oxidase type B, to human brain mitochondria and platelet membranes |
| | Ro 16-6491 Preparation Products And Raw materials |
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