- Rhapontigenin
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- $51.00 / 1mg
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2025-09-30
- CAS:500-65-2
- Min. Order:
- Purity: 99.72%
- Supply Ability: 10g
- Rhapontigenin
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- $0.00 / 1kg
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2025-06-13
- CAS:500-65-2
- Min. Order: 1kg
- Purity: >98%
- Supply Ability: 1000 kg
- Rhapontigenin
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- $0.00 / 25kg
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2024-03-28
- CAS:500-65-2
- Min. Order: 25kg
- Purity: 98%
- Supply Ability: Inquiry
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| Product Name: | rhapontigenin | | Synonyms: | 3-benzenediol;5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1;5-[(1E)-2-(3-HYDROXY-4-METHOXYPHENYL)ETHENYL]-1;3-BENZENEDIOL;5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol;rhapontigenin;(E)-5-[2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol;3,3',5-Trihydroxy-4'-methoxy-trans-stilbene
trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene;(E)-4'-Methoxy-3,3',5-stilbenetriol | | CAS: | 500-65-2 | | MF: | C15H14O4 | | MW: | 258.27 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 500-65-2.mol |  |
| | rhapontigenin Chemical Properties |
| Melting point | 189.0 to 193.0 °C | | Boiling point | 503.6±38.0 °C(Predicted) | | density | 1.345±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | powder to crystal | | pka | 9.17±0.10(Predicted) | | color | White to Light yellow | | InChI | InChI=1S/C15H14O4/c1-19-15-5-4-10(8-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+ | | InChIKey | PHMHDRYYFAYWEG-NSCUHMNNSA-N | | SMILES | C1(O)=CC(/C=C/C2=CC=C(OC)C(O)=C2)=CC(O)=C1 | | CAS DataBase Reference | 500-65-2 |
| | rhapontigenin Usage And Synthesis |
| Description | Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1. | | Description | Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM). | | Uses | Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical] | | Uses | Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1. | | Definition | ChEBI: Rhapontigenin is a stilbenoid. | | in vivo | Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen[3]. | Animal Model: | ICR mice[3] | | Dosage: | 25mg/kg | | Administration: | 25mg/kg; intraperitoneal injection | | Result: | Showed anti-thrombosis activity with 60% protection. |
| | IC 50 | CYP1A1: 400 nM (IC50) | | references | [1]. chun yj, ryu sy, jeong tc, et al. mechanism-based inhibition of human cytochrome p450 1a1 by rhapontigenin. drug metab dispos. 2001 apr;29(4 pt 1):389-93.
[2]. roberti m1, pizzirani d, simoni d, et al. synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. j med chem. 2003 jul 31;46(16):3546-54.
[3]. roupe ka1, helms gl, halls sc, et al. preparative enzymatic synthesis and hplc analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. j pharm pharm sci. 2005 aug 22;8(3):374-86. |
| | rhapontigenin Preparation Products And Raw materials |
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