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20-carboxyarachidonic acid manufacturers
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| | 20-carboxyarachidonic acid Basic information |
| Product Name: | 20-carboxyarachidonic acid | | Synonyms: | (5Z,8Z,11Z,14Z)-icosatetraenedioic acid;20-carboxyarachidonic acid;5(Z),8(Z),11(Z),14(Z)-eicosatetraenedioic acid;5,8,11,14-Eicosatetraenedioic acid, (5Z,8Z,11Z,14Z)- | | CAS: | 79551-84-1 | | MF: | C20H30O4 | | MW: | 334.45 | | EINECS: | | | Product Categories: | | | Mol File: | 79551-84-1.mol |  |
| | 20-carboxyarachidonic acid Chemical Properties |
| Boiling point | 500.7±38.0 °C(Predicted) | | density | 1.037±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 1.5 mg/ml; DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml | | pka | 4.74±0.10(Predicted) |
| | 20-carboxyarachidonic acid Usage And Synthesis |
| Description | 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system. | | Uses | 20-carboxy Arachidonic Acid is a PPARα and PPARγ activator. | | Definition | ChEBI: An alpha,omega-dicarboxylic acid that is (5Z,8Z,11Z,14Z)-icosatetraene in which the two methyl groups are replaced by carboxy groups. | | References | [1] XIANG FANG . 20-Carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ[J]. Prostaglandins & other lipid mediators, 2007, 82 1: Pages 175-184. DOI: 10.1016/j.prostaglandins.2006.05.002 |
| | 20-carboxyarachidonic acid Preparation Products And Raw materials |
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