| Company Name: |
TCI Europe |
| Tel: |
320-37350700 |
| Email: |
sales@tcieurope.eu |
| Company Name: |
TCI AMERICA |
| Tel: |
800-4238616 |
| Email: |
sales@tciamerica.com |
indomethacin farnesil manufacturers
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| | indomethacin farnesil Basic information |
| Product Name: | indomethacin farnesil | | Synonyms: | indomethacin farnesil;1-(4-Chlombenzoyl)-5-methoxy-2-methyl-1-indole-3-acetic acid3，7，11-trimethyl-2，6，10-dodecanetriene ester;Infree;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 3,7,11-trimethyl-2,6,10-dodecatrienyl ester;E-0710;IM-F;Infree S;3,7,11-TriMethyldodeca-2,6,10-trien-1-yl 2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)acetate | | CAS: | 85801-02-1 | | MF: | C34H40ClNO4 | | MW: | 562.14 | | EINECS: | | | Product Categories: | | | Mol File: | 85801-02-1.mol |  |
| | indomethacin farnesil Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Water Solubility | Insoluble in water | | form | clear liquid | | color | Light yellow to Yellow to Orange | | CAS DataBase Reference | 85801-02-1 |
| RTECS | NL3522820 | | HS Code | 2933.79.1500 |
| | indomethacin farnesil Usage And Synthesis |
| Chemical Properties | Acute toxicity LD50 mice, rats, dogs (mg/kg): 6800～7800, 1680～2000, >3000 orally. | | Uses | Indomethacin farnesil is a new type of non-steroidal anti-inflammatory analgesic that is well distributed in inflammatory tissues. It is suitable for rheumatoid arthritis, osteoarthritis, low back pain, periarthritis of the shoulder and shoulder and neck, shoulder and arm syndrome. | | Definition | ChEBI: Indomethacin farnesil is a N-acylindole. | | Synthesis | After indomethacin is chlorinated with thionyl chloride, it reacts with 3,7,1-trimethyl-2,6,10-dodecatrienol in tetrahydrofuran solution in the presence of triethylamine to form indomethacin farnesil. | | in vivo | Indomethacin farnesil (IMF) can effectively release indomethacin when administered locally[1]. | Animal Model: | Rats[1]. | | Dosage: | 50 nmol a rat paw. | | Administration: | Once. | | Result: | Reduced the level of PGE2 in a dose dependent manner. |
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| | indomethacin farnesil Preparation Products And Raw materials |
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