| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
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Product Name:Nemorosone
CAS:351416-47-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Nemorosone
CAS:351416-47-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Nemorosone
CAS:351416-47-2
Purity:98% Package:1mg;5mg;10mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:Nemorosone
CAS:351416-47-2
Package:5mg/RMB 2640;1mg/RMB 770;10mg/RMB 4490
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nemorosone manufacturers
- Nemorosone
-
- $548.00 / 5mg
-
2026-01-05
- CAS:351416-47-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | nemorosone Basic information |
| Product Name: | nemorosone | | Synonyms: | nemorosone;Bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)- (9CI);(1R,5S,7S)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione | | CAS: | 351416-47-2 | | MF: | C33H42O4 | | MW: | 502.68 | | EINECS: | | | Product Categories: | | | Mol File: | 351416-47-2.mol |  |
| | nemorosone Chemical Properties |
| Boiling point | 608.9±55.0 °C(Predicted) | | density | 1.077±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);59.68(Max Conc. mM) | | form | A crystalline solid | | pka | 4.50±1.00(Predicted) | | color | White to off-white |
| | nemorosone Usage And Synthesis |
| Description | Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties. Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM). It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC50s = 4.5-5.0 μM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC50s = >35 μM). It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G0/G1 phase, in both neuroblastoma and pancreatic cancer cells. Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model. | | Uses | Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2]. | | in vivo | Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2]. | Animal Model: | Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2] | | Dosage: | 50 mg/kg | | Administration: | Daily i.p. injections for 28 days | | Result: | Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2]. |
| | References | [1] Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6. DOI:10.3390/ijms21051827
[2] Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5. DOI:10.1371/journal.pone.0074555 |
| | nemorosone Preparation Products And Raw materials |
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