Indotecan hydrochloride

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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Indotecan hydrochloride Basic information
Product Name:Indotecan hydrochloride
Synonyms:Indotecan hydrochloride
CAS:1228035-68-4
MF:C26H26N2O7.ClH
MW:514.96
EINECS:
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Mol File:1228035-68-4.mol
Indotecan hydrochloride Structure
Indotecan hydrochloride Chemical Properties
Safety Information
MSDS Information
Indotecan hydrochloride Usage And Synthesis
UsesIndotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan hydrochloride prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].
References[1] Balaa-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. DOI:10.1128/AAC.00499-12
[2] Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9. DOI:10.1158/1535-7163.MCT-15-0454
Indotecan hydrochloride Preparation Products And Raw materials
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