2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile

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2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile Basic information
Product Name:2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile
Synonyms:2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile
CAS:2873399-22-3
MF:C17H12F2N2O2
MW:314.29
EINECS:
Product Categories:
Mol File:2873399-22-3.mol
2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile Structure
2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile Chemical Properties
Boiling point 477.3±45.0 °C(Predicted)
density 1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka3.11±0.40(Predicted)
Safety Information
MSDS Information
2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile Usage And Synthesis
UsesTubulin polymerization-IN-2 is a potent anticancer agent targeting to β-tubulin with an IC50 value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines[1].
References[1] Elshemy HAH, et al. Development of potential anticancer agents and apoptotic inducers based on 4-aryl-4H chromene scaffold: Design, synthesis, biological evaluation and insight on their proliferation inhibition mechanism. Bioorg Chem. 2022 Jan;118:105475. DOI:10.1016/j.bioorg.2021.105475
2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile Preparation Products And Raw materials
Tag:2-Amino-4-(3,4-difluorophenyl)-7-methoxy-4H-1-benzopyran-3-carbonitrile(2873399-22-3) Related Product Information
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