YM17E manufacturers
- YM17E
-
- $53.00
-
2026-07-14
- CAS:124900-72-7
- Purity: 99.29%
- Supply Ability: 10g
- YM17E
-
- $53.00
-
2026-07-14
- CAS:124900-72-7
- Purity: 99.29%
- Supply Ability: 10g
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| Product Name: | YM17E | | Synonyms: | YM17E;Urea, N,N''-[1,3-phenylenebis(methylene)]bis[N-cycloheptyl-N'-[4-(dimethylamino)phenyl]- (9CI);Diglyceride acyltransferase,Inhibitor,acyl-CoA:cholesterol acyltransferase,inhibit,YM17E,Acyltransferase,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,YM-17E;1,1'-(1,3-Phenylenebis(methylene))bis(1-cycloheptyl-3-(4-(dimethylamino)phenyl)urea);YM17E, 10 mM in DMSO | | CAS: | 124900-72-7 | | MF: | C40H56N6O2 | | MW: | 652.93 | | EINECS: | | | Product Categories: | | | Mol File: | 124900-72-7.mol |  |
| | YM17E Chemical Properties |
| Boiling point | 862.7±65.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 14.03±0.70(Predicted) | | color | White to off-white |
| | YM17E Usage And Synthesis |
| Uses | YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro. | | Biological Activity | YM17E is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50 of 44 nM in vitro in rabbit liver microsomes. | | in vitro | YM17E is as potent in inhibiting ACAT activity in the liver as in the intestine, with IC 50 values of 45 and 34 nM, respectively. | | in vivo | YM17E (3, 10 and 30 mg/kg per day, p.o.) decreases total cholesterol, cholesteryl ester and non-HDL cholesterol in a dose-dependent manner. Total cholesterol and cholesteryl ester levels in liver do not decrease significantly after intravenous administration of YM17E, but do decrease significantly and in a dose-dependent manner after oral administration. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats after both oral and intravenous administration[1]. YM17E inhibits production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[2]. | | target | IC50: 44 nM (ACAT in rabbit liver microsomes) | | References | [1] Uchida T, et al. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats. Atherosclerosis. 1998 Mar;137(1):97-106. DOI:10.1016/s0021-9150(97)00259-1
[2] Kashiwa M, et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50. DOI:10.1254/jjp.73.41 |
| | YM17E Preparation Products And Raw materials |
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