| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Gemcitabine-13C,15N2 (hydrochloride)
CAS:2757566-59-7
Purity:98% Package:500μg;1mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Gemcitabine-13C,15N2 (hydrochloride)
CAS:2757566-59-7
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Gemcitabine-13C,15N2 (hydrochloride)
CAS:2757566-59-7
|
|
| | Gemcitabine-13C,15N2 (hydrochloride) Basic information |
| | Gemcitabine-13C,15N2 (hydrochloride) Chemical Properties |
| form | Solid | | color | White to off-white |
| | Gemcitabine-13C,15N2 (hydrochloride) Usage And Synthesis |
| Uses | Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80 PMID:21965724
[3] Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer18(2):198-206 DOI:10.1089/jam.2005.18.198
[4] Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2292(22):9136-9149. DOI:10.1074/jbc.M117.783365
[5] Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 1713:194. DOI:10.1186/1471-2407-13-194 |
| | Gemcitabine-13C,15N2 (hydrochloride) Preparation Products And Raw materials |
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