- Isoliquiritin apioside
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- $0.00 / 5mg
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2023-02-24
- CAS:120926-46-7
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- isoliquiritin apioside
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- $1.00 / 1KG
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2019-07-14
- CAS:120926-46-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 25kg
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| | isoliquiritin apioside Basic information |
| Product Name: | isoliquiritin apioside | | Synonyms: | isoliquiritin apioside;(2E)-3-[4-[(2-O-D-apio-beta-D-furanosyl-beta-D-glucopyranosyl)oxy]phenyl]-1-(2,4-dihydroxyphenyl)-2-propen-1-one;Soliquiritin apioside;Neolicuroside;(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 3-[4-[(2-O-D-apio-β-D-furanosyl-β-D-glucopyranosyl)oxy]phenyl]-1-(2,4-dihydroxyphenyl)-, (2E)-;isoliquiritin apioside USP/EP/BP;(E)-3-(4-(((2S,3R,4S,5S,6R)-3-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one | | CAS: | 120926-46-7 | | MF: | C26H30O13 | | MW: | 550.51 | | EINECS: | | | Product Categories: | | | Mol File: | 120926-46-7.mol |  |
| | isoliquiritin apioside Chemical Properties |
| Boiling point | 901.0±65.0 °C(Predicted) | | density | 1.63 | | storage temp. | -20°C, protect from light | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 7.46±0.35(Predicted) | | color | Yellow to orange | | biological source | plant | | Water Solubility | water: slightly soluble | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChIKey | VMMVZVPAYFZNBM-KVFWHIKKSA-N | | SMILES | O([C@@H]1OC[C@]([C@H]1O)(O)CO)[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC1C=CC(=CC=1)/C=C/C(C1C=CC(=CC=1O)O)=O)CO)O)O | | CAS DataBase Reference | 120926-46-7 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | isoliquiritin apioside Usage And Synthesis |
| Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from licorice. | | Uses | Isoliquiritin apioside can be used to resist myocardial ischemia and inhibit the proliferation of HIV. | | Definition | ChEBI: Neolicuroside is a member of flavonoids and a glycoside. | | Biological Activity | Neolicuroside modulates signaling pathways (e.g., MAPK, NF-KB), impacting vital cell processes such as proliferation, differentiation, and apoptosis. Its multitargeted mechanism includes scavenging free radicals, suppressing pro-inflammatory cytokine production, inhibiting matrix metalloproteinase (MMP) activity and hindering cancer cell growth through apoptosis and cell cycle arrest. Furthermore, it also exerts immunomodulatory effects possibly by activating toll-like receptor 4 (TLR4). | | Synthesis | Dried Glycyrrhiza glabra 5.0 kg was extracted with 8 times and 6 times amount of 95% ethanol aqueous solution at reflux for 2 times, each time for 1 h. The extracts were combined, concentrated to a certain concentration under reduced pressure, and then placed on a column equipped with D101 macroporous resin, respectively, eluted with water, and 40% and 95% ethanol, and then the 40% ethanol eluent was collected, and then concentrated to a suitable concentration under reduced pressure for semi-preparative liquid chromatography, and the separation was carried out with the gradient elution of acetonitrile-water (10901000). Gradient elution of acetonitrile-water (10:90100:0) gave compounds 1 (3.9 mg), 2 (4.6 mg), 3 (3.3 mg) and 4 (3.0 mg). The 95% ethanol eluate was collected and further separated by ODS medium pressure column chromatography using 55% methanol and pure methanol solvent elution. The pure methanol eluate was collected for concentration under reduced pressure and freeze-dried to obtain dry powder (28 g). 0.43g of dried powder was dissolved in methanol and separated by semi-preparative liquid chromatography, acetonitrile-water to obtain apigenin (2.7mg). | | IC 50 | MMP9; NF-κB; p38 MAPK |
| | isoliquiritin apioside Preparation Products And Raw materials |
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