6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole

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6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole Suppliers list
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6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole manufacturers

  • STM3006
  • STM3006 pictures
  • $88.00
  • 2026-06-09
  • CAS:2499664-52-5
  • Purity: 97.28%
  • Supply Ability: 10g
6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole Basic information
Product Name:6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole
Synonyms:6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole;6-Bromo-4-(1-((6-((4,4-dimethylpiperidin-1-yl)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)-1H-indazole
CAS:2499664-52-5
MF:C25H27BrN8
MW:519.44
EINECS:
Product Categories:
Mol File:2499664-52-5.mol
6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole Structure
6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole Chemical Properties
density 1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka11.05±0.40(Predicted)
form Solid
color Light yellow to brown
Safety Information
MSDS Information
6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole Usage And Synthesis
UsesSTM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC50: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results[1][2].
References[1] Andrew A Guirguis, et al. Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.Cancer Discov. 2023 Oct 5;13(10):2228-2247. DOI:10.1158/2159-8290.CD-23-0007
[2] Brichkina A, et al. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduct Target Ther. 2023 Dec 11;8(1):448. DOI:10.1038/s41392-023-01696-x
6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole Preparation Products And Raw materials
Tag:6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole(2499664-52-5) Related Product Information
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