| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:E-5324
CAS:141799-76-0
Package:25mg/RMB 13900;50mg/RMB 18300;100mg/RMB 23500
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E 5324 manufacturers
- E-5324
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- $1970.00
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2026-05-11
- CAS:141799-76-0
- Purity:
- Supply Ability: 10g
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| Product Name: | E 5324 | | Synonyms: | E 5324;Urea, N-butyl-N'-[2-[3-(5-ethyl-4-phenyl-1H-imidazol-1-yl)propoxy]-6-methylphenyl]-;E5324,E 5324 | | CAS: | 141799-76-0 | | MF: | C26H34N4O2 | | MW: | 434.57 | | EINECS: | | | Product Categories: | | | Mol File: | 141799-76-0.mol |  |
| | E 5324 Chemical Properties |
| Boiling point | 637.4±55.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 14.20±0.46(Predicted) |
| | E 5324 Usage And Synthesis |
| Uses | E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM. | | in vivo | The areas under the cholesterol-time curves for duration of this study (AUC) for control, E-5324 0.02% and E-5324 0.1% are 104985±4411, 106096±4476 and 105231±4 348 mg×day/dL, respectively. The high dose of E-5324 (0.1%) significantly reduces the surface involvement by 34% and 54% in the aortic arch and thoracic aorta, respectively. E-5324 treatment significantly reduces the wet weight and protein content. In the aortic arch, the high dose of E-5324 (0.1%) significantly reduces both cholesteryl ester and total cholesterol by 60% and 59%, respectively. The high dose of E-5324 (0.1%) markedly reduces the ACAT activities in the aortic arch and thoracic aorta by 35% and 44%, respectively[2]. | | References | [1] Kogushi M, et al. Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages. Jpn J Pharmacol. 1995 Jun;68(2):191-9. DOI:10.1254/jjp.68.191
[2] Kogushi M, et al. Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA:cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits. Atherosclerosis. 1996 Aug 2;124(2):203-10. DOI:10.1016/0021-9150(96)05831-5 |
| | E 5324 Preparation Products And Raw materials |
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