GTS-21盐酸盐
| 中文名称 | GTS-21盐酸盐 |
|---|---|
| 中文同义词 | GTS-21盐酸盐;(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐;GTS-21二盐酸盐;GTS-21二盐酸盐(DMBX-A)≥98%;(E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐;化合物GTS 21 DIHYDROCHLORIDE;GTS-21二盐酸盐(DMBX-A);(E)-3-(2,4-二甲氧基苄亚基)-3,4,5,6-四氢-2,3'-联吡啶 盐酸盐 |
| 英文名称 | 3-(2,4-dimethoxybenzylidene)anabaseine |
| 英文同义词 | 3-(2,4-dimethoxybenzylidene)anabaseine;3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride;3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl;3-(2,4)-DiMethoxybenzylidineanabaseine;GTS-21 (DMXB-A);3-(2,4-DiMethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl Dihydrochloride;(3E)-3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine dihydrochloride;DMBX-anabaseine |
| CAS号 | 156223-05-1 |
| 分子式 | C19H22Cl2N2O2 |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;原料;Inhibitors |
| Mol文件 | 156223-05-1.mol |
| 结构式 |  |
GTS-21盐酸盐 性质
| 熔点 | 216-217℃ (decomposition) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 在水中的溶解度>5mg/mL |
| 形态 | 粉末 |
| 颜色 | 淡黄色至深黄色 |
| 水溶解性 | H2O: >5mg/mL |
| InChI | 1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;; |
| InChIKey | RPYWXZCFYPVCNQ-RVDMUPIBSA-N |
| SMILES | Cl.Cl.COc1ccc(\C=C2/CCCN=C2c3cccnc3)c(OC)c1 |
GTS-21 dihydrochloride 是一种选择性 α7 烟碱乙酰胆碱受体 (α7-nAChR) 激动剂，具有抗炎和增强认知的活性。GTS-21 dihydrochloride 也是 α4β2 (human α4β2: Ki=20 nM) 和 5-HT3A 受体 (IC50=3.1 μM) 拮抗剂。
|
α7-nAChR
|
human α4β2 20 nM (Ki) |
5-HT 3A Receptor 3.1 μM (IC 50 ) |
GTS-21 bound to human α4β2 nAChR (K i =20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.
GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury.
| Animal Model: | C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI) |
| Dosage: | 4 mg/kg |
| Administration: | I.p.; 1, 3, 7, 14 and 21 days |
| Result: | Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice. |
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | DW1764860 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-14564A | GTS-21盐酸盐 GTS-21 dihydrochloride | 156223-05-1 | 1 mg | 272元 |
| 2025/12/22 | HY-14564A | (3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐 GTS-21 dihydrochloride | 156223-05-1 | 5mg | 530元 |