NSC 366140 无结构图
| 中文名称 | NSC 366140 无结构图 |
|---|---|
| 中文同义词 | NSC 366140 无结构图;化合物 T28475;化合物PYRAZOLOACRIDINE;化合物PYRAZOLOACRIDINE,10 MM DMSO 溶液 |
| 英文名称 | NSC 366140 |
| 英文同义词 | Pyrazolo(3,4,5-kl)acridine-2(6H)-propanamine, N,N-dimethyl-9-methoxy-5-nitro-;(3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE;NSC 366140;2,6-Dihydro-2-(3-dimethylaminopropyl)-9-methoxy-5-nitropyrazolo[3,4,5-kl]acridine;9-Methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-propane-1-amine;Pyrazoloacridine;1,2,6,10b-Tetrahydro-5-nitro-9-methoxy-2-[3-(dimethylamino)propyl]pyrazolo[3,4,5-kl]acridine;Brn 4211902 |
| CAS号 | 99009-20-8 |
| 分子式 | C19H21N5O3 |
| 分子量 | 367.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 99009-20-8.mol |
| 结构式 |  |
NSC 366140 无结构图 性质
| 沸点 | 584.3±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.35±0.28(Predicted) |
| 颜色 | 浅棕色至橙色 |
Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓扑异构酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 对 K562 髓系白血病细胞中的 IC50 值为 1.25 μM (24 h)。
Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC
50
values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells.
Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro.
Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer.
Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells.
Pyrazoloacridine (NSC 366140) induces
apoptosis
in P53-deficient Hep 3B human hepatoma cells.
Cell Cytotoxicity Assay
| Cell Line: | K562 Myeloid Leukemia Cells. |
| Concentration: | 0-500 μM. |
| Incubation Time: | 1 h or 24 h. |
| Result: | When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC 50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC 50 was 1.25 μM. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-108969 | NSC 366140 无结构图 Pyrazoloacridine | 99009-20-8 | 1 mg | 466元 |
| 2025/12/22 | HY-108969 | NSC 366140 无结构图 Pyrazoloacridine | 99009-20-8 | 10 mM * 1 mLin DMSO | 727元 |
上游原料