- 2-Bromo-4-butanolide
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- $1.00
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2026-06-26
- CAS:5061-21-2
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1000kg
- 2-Bromo-4-butanolide
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- $10.00
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2026-05-28
- CAS:5061-21-2
- Min. Order: 1KG
- Purity: 99.8%
- Supply Ability: 100tons
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| | 2-Bromo-4-butanolide Basic information |
| | 2-Bromo-4-butanolide Chemical Properties |
| Boiling point | 138 °C/6 mmHg (lit.) | | density | 1.786 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.508(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | Acetone, Chloroform, Ethyl Acetate, Methanol | | form | Clear Colourless to Light Yellow Liquid | | Specific Gravity | 1.778 (20/4℃) | | Appearance | Colorless to light yellow Liquid | | Sensitive | Moisture Sensitive/Lachrymatory | | BRN | 107800 | | InChI | InChI=1S/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2 | | InChIKey | LFJJGHGXHXXDFT-UHFFFAOYSA-N | | SMILES | O1CCC(Br)C1=O | | CAS DataBase Reference | 5061-21-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2(3H)-Furanone, 3-bromodihydro-(5061-21-2) | | EPA Substance Registry System | 2(3H)-Furanone, 3-bromodihydro- (5061-21-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 2810 | | WGK Germany | 3 | | F | 21 | | Hazard Note | Irritant/Keep Cold/Lachrymatory/Moisture Sensitive | | TSCA | TSCA listed | | HS Code | 29322980 | | Storage Class | 10 - Combustible liquids |
| | 2-Bromo-4-butanolide Usage And Synthesis |
| Chemical Properties | Pale Yellow Liquid | | Uses | Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1. | | Synthesis | General procedure for the synthesis of α-bromo-γ-butyrolactone from γ-butyrolactone (bromination step): in a 1000 mL reaction vessel equipped with a stirring device, refluxing device, thermometer, dropping funnel, and nitrogen introduction tube, 200 g (2.32 mol) of γ-butyrolactone and 2.76 g (0.086 mol based on 3.7 mol% of γ-butyrolactone) of sulfur were added as the catalyst. 431 g (2.70 mol) of bromine was loaded into a dropping funnel. Stirring was initiated, the reaction temperature was controlled not to exceed 40 °C, and the bromine was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to about 90 °C and the reaction was maintained at this temperature for 1 hour. Subsequently, the temperature was raised to about 110°C and the reaction was continued for 3 hours. | | References | [1] Patent: JP5837752, 2015, B2. Location in patent: Paragraph 0052; 0079-0081; 0082; 0085; 0086; 0088
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 1, p. 89 - 100
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[4] Synlett, 2005, # 17, p. 2648 - 2652
[5] Organic Letters, 2011, vol. 13, # 14, p. 3670 - 3673 |
| | 2-Bromo-4-butanolide Preparation Products And Raw materials |
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