3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate

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3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate manufacturers

  • Azt-pmap
  • Azt-pmap pictures
  • $1820.00
  • 2026-07-27
  • CAS:142629-81-0
  • Purity:
  • Supply Ability: 10g
  • Azt-pmap
  • Azt-pmap pictures
  • $1820.00
  • 2026-07-27
  • CAS:142629-81-0
  • Purity:
  • Supply Ability: 10g
  • Azt-pmap
  • Azt-pmap pictures
  • $1820.00
  • 2025-07-24
  • CAS:142629-81-0
  • Purity:
  • Supply Ability: 10g
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate Basic information
Product Name:3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate
Synonyms:3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate;Azt-pmap;Azt pmap,Aztpmap;3'-AZIDOTHYMIDINE-5'-(PHENYLMETHOXYALANYL)PHOSPHO...;sodium (2R,4S,5S,6R)-5-acetamido-6-((1S,2S)-3-azido-1,2-dihydroxypropyl)-2-carboxy-4-hydroxytetrahydro-2H-pyran-2-yl (((2R,3S,4R,5R)-5-(4-amino-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl) phosphate
CAS:142629-81-0
MF:C20H25N6O8P
MW:508.421661
EINECS:
Product Categories:
Mol File:142629-81-0.mol
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate Structure
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate Chemical Properties
Safety Information
MSDS Information
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate Usage And Synthesis
UsesAzt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection[2]. Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50HIV-1
References[1] McGuigan C, et al. Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT. Antiviral Res. 1992 Apr;17(4):311-21. DOI:10.1016/0166-3542(92)90026-2
[2] Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8(4):e62196. DOI:10.1371/journal.pone.0062196
3'-azidothymidine-5'-(phenylmethoxyalanyl)phosphate Preparation Products And Raw materials
Raw materialsThymidine, 3'-azido-3'-deoxy-, 5'-(phenyl phosphonate)-->methyl L-alaninate-->Phenyl phosphorodichloridite
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