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| | AVLX-125 Basic information |
| | AVLX-125 Chemical Properties |
| Boiling point | 1713.029±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.307±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 2.895±0.10(predicted) | | Sequence | Val-Asp-Thr-Glu-Ile-Ile-Glu-Thr-Asp-Val Covalent bridge:Ile5-Ile6 |
| | AVLX-125 Usage And Synthesis |
| Uses | AVLX-125 (UCCB01-125) is a PSD-95 and PDZ domain inhibitor with Kd value of 10 nM. AVLX-125 can be used in the study of inflammatory pain[1][2]. | | References | [1] Haugaard-Kedstrm L M, et al. Targeting PSD-95 as a novel approach in the treatment of stroke. Neuroprotective Therapy for Stroke and Ischemic Disease, 2017: 157-184.
[2] Andreasen JT, et al. UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801. Neuropharmacology. 2013 Apr;67:193-200. DOI:10.1016/j.neuropharm.2012.11.006 |
| | AVLX-125 Preparation Products And Raw materials |
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