Smurf1-IN-1 manufacturers
- Smurf1-IN-1
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- $2500.00
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2026-07-27
- CAS:1824708-03-3
- Purity:
- Supply Ability: 10g
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| | Smurf1-IN-1 Basic information |
| Product Name: | Smurf1-IN-1 | | Synonyms: | Smurf1-IN-1;1H-1,2,3-Triazole-4-carboxamide, 1-(2-chloro-4-cyclopropylphenyl)-N-(2-cyclohexyl-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazol-4-yl)-5-methyl- | | CAS: | 1824708-03-3 | | MF: | C24H29ClN6O2 | | MW: | 468.98 | | EINECS: | | | Product Categories: | | | Mol File: | 1824708-03-3.mol |  |
| | Smurf1-IN-1 Chemical Properties |
| density | 1.449±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 6.550±0.20(predicted) | | form | Solid | | color | Off-white to pink |
| | Smurf1-IN-1 Usage And Synthesis |
| Uses | Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1]. | | References | [1] Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139. DOI:10.1021/acs.jmedchem.3c00229 |
| | Smurf1-IN-1 Preparation Products And Raw materials |
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