BRD4 Inhibitor-28 manufacturers
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| | BRD4 Inhibitor-28 Basic information |
| Product Name: | BRD4 Inhibitor-28 | | Synonyms: | BRD4 Inhibitor-28;Imidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one, 8-(1,6-dihydro-1,5-dimethyl-6-oxo-3-pyridinyl)-4,5-dihydro-1-(phenylmethyl)- | | CAS: | 2468960-80-5 | | MF: | C23H21N3O3 | | MW: | 387.43 | | EINECS: | | | Product Categories: | | | Mol File: | 2468960-80-5.mol |  |
| | BRD4 Inhibitor-28 Chemical Properties |
| Boiling point | 630.533±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.397±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 2.233±0.20(predicted) |
| | BRD4 Inhibitor-28 Usage And Synthesis |
| Uses | BRD4 Inhibitor-28 (Compound 18) is an orally active BRD4 Inhibitor. BRD4 Inhibitor-28 inhibits BRD40-BD1, BRD40-BD2 with IC50s of 15, 55 nM. BRD4 Inhibitor-28 also inhibits BRD2-BD1, BRD3-BD1, BRDT-BD1 with IC50s of 19, 25, 68 nM. BRD4 Inhibitor-28 has anti-melanoma activity[1]. | | References | [1] Horai Y, et al. Discovery of a potent, orally available tricyclic derivative as a novel BRD4 inhibitor for melanoma. Bioorg Med Chem. 2023 Aug 26;93:117461. DOI:10.1016/j.bmc.2023.117461 |
| | BRD4 Inhibitor-28 Preparation Products And Raw materials |
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