Soluble Epoxide Hydrolase PROTAC 1a

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Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Company Name: Neobioscience Co., Ltd.  
Tel: 4006-800-892
Email: info@neobioscience.com
Soluble Epoxide Hydrolase PROTAC 1a Basic information
Product Name:Soluble Epoxide Hydrolase PROTAC 1a
Synonyms:Soluble Epoxide Hydrolase PROTAC 1a
CAS:
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MW:0
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Mol File:Mol File
Soluble Epoxide Hydrolase PROTAC 1a Structure
Soluble Epoxide Hydrolase PROTAC 1a Chemical Properties
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Soluble Epoxide Hydrolase PROTAC 1a Usage And Synthesis
DescriptionSoluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) that contains cereblon ligand 1 (Item No. 21589) connected to the sEH inhibitor t-TUCB (Item No. 36384) by a linker region.1 It drives sEH degradation and selectively inhibits the hydrolase activity of sEH (IC50 = 0.8 nM) over its phosphatase activity (IC50 = >10,000 nM). sEH PROTAC 1a is also selective for the degradation of cytosolic over peroxisomal sEH and drives its degradation via the lysosome rather than the proteasome. It reduces thapsigargin-induced increases in phosphorylated inositol-requiring enzyme 1α (IRE1α) levels and X-box binding protein 1 (XBP1) splicing in HepG2 and 293T cells, indicating a reduction in ER stress.WARNING This product is not for human or veterinary use.
Soluble Epoxide Hydrolase PROTAC 1a Preparation Products And Raw materials
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