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| | PROTAC SMARCA2 degrader-2 Basic information |
| Product Name: | PROTAC SMARCA2 degrader-2 | | Synonyms: | PROTAC SMARCA2 degrader-2;(2S,4R)-4-hydroxy-1-[(2R)-2-{3-[2-(4-{[3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyridazino[3,4-b]pyrazin]-1-yl]methyl}piperidin-1-yl)ethoxy]-1,2-oxazol-5-yl}-3-methylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[2-[4-[[7′,8′-dihydro-3′-(2-hydroxyphenyl)spiro[piperidine-4,6′(5′H)-pyrazino[2,3-c]pyridazin]-1-yl]methyl]-1-piperidinyl]ethoxy]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)- | | CAS: | 2892523-74-7 | | MF: | C49H62N10O6S | | MW: | 919.15 | | EINECS: | | | Product Categories: | | | Mol File: | 2892523-74-7.mol |  |
| | PROTAC SMARCA2 degrader-2 Chemical Properties |
| density | 1.380±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 8.492±0.35(predicted) |
| | PROTAC SMARCA2 degrader-2 Usage And Synthesis |
| Uses | PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC50 of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research[1]. | | References | [1] Liang Lu, et al. Brm targeting compounds and associated methods of use. Patent WO2023287787A1. |
| | PROTAC SMARCA2 degrader-2 Preparation Products And Raw materials |
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