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| Product Name: | BT11 | | Synonyms: | BT11;[4-[6-(1~{H}-benzimidazol-2-yl)pyridine-2-carbonyl]piperazin-1-yl]-[6-(1~{H}-benzimidazol-2-yl)pyridin-2-yl]methanone;BT11;BT 11;BT-11, >98%;Methanone, 1,1'-(1,4-piperazinediyl)bis[1-[6-(1H-benzimidazol-2-yl)-2-pyridinyl]-;Omilancor;piperazine-1,4-diylbis((6-(1H-benzo[d]imidazol-2-yl)pyridin-2-yl)methanone);Omilancor (BT-11) | | CAS: | 1912399-75-7 | | MF: | C30H24N8O2 | | MW: | 528.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1912399-75-7.mol |  |
| Boiling point | 923.4±75.0 °C(Predicted) | | density | 1.424±0.06 g/cm3(Predicted) | | solubility | DMSO: Soluble: =10 mg/ml | | form | Solid | | pka | 10.24±0.10(Predicted) |
| Uses | BT-11 is an orally available LANCL2 binding compound for treating inflammatory bowel disease. | | Biological Activity | BT11 is an orally active compound that binds to lanthionine synthetase C-like 2 (LANCL2) with a Kd value of 7.7 μM and can be used for the treatment of inflammatory bowel disease. | | in vivo | Oral administration of 8 mg/kg/day BT-11 to mice attenuates colitis. In the drug safety testing experiment in rats, oral high concentrations of BT-11 have good safety (detection concentration up to 1000 mg/kg/day). | | target | | Target | Value | LANCL2
() | | References | [1] Carbo A, et al. An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease. J Med Chem. 2016 Nov 23;59(22):10113-10126. DOI:10.1021/acs.jmedchem.6b00412
[2] Bissel P, et al. Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease. Int J Toxicol. 2016 Sep;35(5):521-9. DOI:10.1177/1091581816646356
[3] ANDREW LEBER. Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms.[J]. Inflammatory Bowel Diseases, 2018, 24 9: 1978-1991. DOI: 10.1093/ibd/izy167 |
| | BT11 Preparation Products And Raw materials |
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Tag:BT11(1912399-75-7)
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