CDK5-IN-4

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CDK5-IN-4 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
CDK5-IN-4 Basic information
Product Name:CDK5-IN-4
Synonyms:CDK5-IN-4
CAS:1212711-91-5
MF:C24H24FN5O3
MW:449.48
EINECS:
Product Categories:
Mol File:1212711-91-5.mol
CDK5-IN-4 Structure
CDK5-IN-4 Chemical Properties
density 1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.02±0.40(predicted)
Safety Information
MSDS Information
CDK5-IN-4 Usage And Synthesis
UsesCDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research[1].
IC 50GSK-3α: 0.98 ± 0.0 μM (IC50); GSK-3β: 4.00 ± 1.3 μM (IC50); CDK9: 1.76 ± 0.3 μM (IC50); CDK2: 6.24 ± 2.8 μM (IC50); CDK5: 9.8 ± 2.29 μM (IC50)
References[1] Khan ZR, et al. Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma. J Med Chem. 2024 Apr 30. DOI:10.1021/acs.jmedchem.4c00373
CDK5-IN-4 Preparation Products And Raw materials
Tag:CDK5-IN-4(1212711-91-5) Related Product Information
THZ1 GSK-3326595 DRB INX-315 CDK2 Protein, HUMAN (HIS) PCTAIRE1 Protein, Human (sf9, GST)