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| | EZH2-IN-17 Basic information |
| Product Name: | EZH2-IN-17 | | Synonyms: | EZH2-IN-17;Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[2,3-dihydro-1-(4-morpholinyl)-1H-inden-5-yl]-3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-methyl- | | CAS: | 2489672-09-3 | | MF: | C36H46N4O4 | | MW: | 598.78 | | EINECS: | | | Product Categories: | | | Mol File: | 2489672-09-3.mol |  |
| | EZH2-IN-17 Chemical Properties |
| Boiling point | 778.664±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.183±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 11.793±0.10(predicted) |
| | EZH2-IN-17 Usage And Synthesis |
| Uses | EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1]. | | References | [1] Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2). Bioorg Med Chem Lett. 2023 Nov 11:129558. DOI:10.1016/j.bmcl.2023.129558 |
| | EZH2-IN-17 Preparation Products And Raw materials |
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