|
|
| | HSD17B13-IN-54 Basic information |
| Product Name: | HSD17B13-IN-54 | | Synonyms: | HSD17B13-IN-54;Benzamide, 3,5-dichloro-N-[8-fluoro-3,4-dihydro-2-methyl-4-oxo-3-[[2-(trifluoromethyl)phenyl]methyl]-5-quinazolinyl]-4-hydroxy- | | CAS: | 2770247-49-7 | | MF: | C24H15Cl2F4N3O3 | | MW: | 540.29 | | EINECS: | | | Product Categories: | | | Mol File: | 2770247-49-7.mol |  |
| | HSD17B13-IN-54 Chemical Properties |
| density | 1.539±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 5.318±0.25(predicted) |
| | HSD17B13-IN-54 Usage And Synthesis |
| Uses | HSD17B13-IN-54 (Compound 158) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-54 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI)[1]. | | References | [1] Anandan S K, et al. Dichlorophenol HSD17B13 inhibitors and uses thereof. U.S., WO2022103960. 2023-11-28. |
| | HSD17B13-IN-54 Preparation Products And Raw materials |
|