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| | Mcl-1 inhibitor 10 Basic information |
| Product Name: | Mcl-1 inhibitor 10 | | Synonyms: | Mcl-1 inhibitor 10;[1,1′-Biphenyl]-3-carboxylic acid, 4-hydroxy-2′-[[3-(trifluoromethyl)phenoxy]methyl]- | | CAS: | 1580484-33-8 | | MF: | C21H15F3O4 | | MW: | 388.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1580484-33-8.mol |  |
| | Mcl-1 inhibitor 10 Chemical Properties |
| Melting point | 158 °C | | Boiling point | 537.315±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.368±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 3.062±0.10(predicted) |
| | Mcl-1 inhibitor 10 Usage And Synthesis |
| Uses | Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of MCL-1 protein to block the pro-survival signal of MCL-1 and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of MCL-1 dependent cancers[1]. | | References | [1] Petros A M, et al. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein[J]. Bioorganic & medicinal chemistry letters, 2014, 24(6): 1484-1488. DOI:10.1016/j.bmcl.2014.02.010 |
| | Mcl-1 inhibitor 10 Preparation Products And Raw materials |
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