mGluR5 antagonist-1

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mGluR5 antagonist-1 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
mGluR5 antagonist-1 Basic information
Product Name:mGluR5 antagonist-1
Synonyms:mGluR5 antagonist-1;7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, N-(4-methoxyphenyl)-7-methyl-4-(2-phenylethynyl)-
CAS:2761424-76-2
MF:C23H18N4O2
MW:382.42
EINECS:
Product Categories:
Mol File:2761424-76-2.mol
mGluR5 antagonist-1 Structure
mGluR5 antagonist-1 Chemical Properties
Boiling point 545.5±50.0 °C(predicted)
density 1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.63±0.70(predicted)
form Solid
color Off-white to yellow
Safety Information
MSDS Information
mGluR5 antagonist-1 Usage And Synthesis
UsesmGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1].
References[1] Yonglei Du, et al. Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice. Eur J Med Chem. 2023. DOI:10.1016/j.ejmech.2023.115855
mGluR5 antagonist-1 Preparation Products And Raw materials
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