| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PROTAC IRAK4 degrader-8
CAS:2911615-06-8
Package:5mg;50mg
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PROTAC IRAK4 degrader-8 manufacturers
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| | PROTAC IRAK4 degrader-8 Basic information |
| Product Name: | PROTAC IRAK4 degrader-8 | | Synonyms: | PROTAC IRAK4 degrader-8;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[trans-4-[[9-[4-chloro-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoyl]-3,9-diazaspiro[5.5]undec-3-yl]methyl]cyclohexyl]-3-(difluoromethyl)-1H-pyrazol-4-yl]-5-(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl- | | CAS: | 2911615-06-8 | | MF: | C43H50ClF2N11O5 | | MW: | 874.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2911615-06-8.mol |  |
| | PROTAC IRAK4 degrader-8 Chemical Properties |
| density | 1.615±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 8.205±0.46(predicted) |
| | PROTAC IRAK4 degrader-8 Usage And Synthesis |
| Uses | PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1]. | | References | [1] Ye Zhengqing. IRAK4 degradation agent, preparation method and application thereof. Patent. CN115710274.
[2] Ye Z, et al. Preparation of (pyrazolyl)pyrazolo[1,5-a]pyrimidinyl carboxamide derivatives as IRAK4 degrading agents and its applications. China, CN115710274 A. 2023-02-24. |
| | PROTAC IRAK4 degrader-8 Preparation Products And Raw materials |
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