PROTAC IRAK4 degrader-8

PROTAC IRAK4 degrader-8 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PROTAC IRAK4 degrader-8
CAS:2911615-06-8
Package:5mg;|50mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:PROTAC IRAK4 degrader-8
CAS:2911615-06-8
Package:5mg;50mg

PROTAC IRAK4 degrader-8 manufacturers

PROTAC IRAK4 degrader-8 Basic information
Product Name:PROTAC IRAK4 degrader-8
Synonyms:PROTAC IRAK4 degrader-8;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[trans-4-[[9-[4-chloro-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoyl]-3,9-diazaspiro[5.5]undec-3-yl]methyl]cyclohexyl]-3-(difluoromethyl)-1H-pyrazol-4-yl]-5-(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-
CAS:2911615-06-8
MF:C43H50ClF2N11O5
MW:874.38
EINECS:
Product Categories:
Mol File:2911615-06-8.mol
PROTAC IRAK4 degrader-8 Structure
PROTAC IRAK4 degrader-8 Chemical Properties
density 1.615±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka8.205±0.46(predicted)
Safety Information
MSDS Information
PROTAC IRAK4 degrader-8 Usage And Synthesis
UsesPROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1].
References[1] Ye Zhengqing. IRAK4 degradation agent, preparation method and application thereof. Patent. CN115710274.
[2] Ye Z, et al. Preparation of (pyrazolyl)pyrazolo[1,5-a]pyrimidinyl carboxamide derivatives as IRAK4 degrading agents and its applications. China, CN115710274 A. 2023-02-24.
PROTAC IRAK4 degrader-8 Preparation Products And Raw materials
Tag:PROTAC IRAK4 degrader-8(2911615-06-8) Related Product Information

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