| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ALK5-IN-82
CAS:3001361-04-9
Package:50mg/RMB 15900
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| | ALK5-IN-82 Basic information |
| Product Name: | ALK5-IN-82 | | Synonyms: | ALK5-IN-82;2-Thiopheneacetamide, N-[[5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazol-2-yl]methyl]- | | CAS: | 3001361-04-9 | | MF: | C22H19N7OS | | MW: | 429.5 | | EINECS: | | | Product Categories: | | | Mol File: | 3001361-04-9.mol |  |
| | ALK5-IN-82 Chemical Properties |
| density | 1.462±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 8.295±0.10(predicted) |
| | ALK5-IN-82 Usage And Synthesis |
| Uses | ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis[1]. | | References | [1] Yang YX, et al. Synthesis of amide derivatives containing the imidazole moiety and evaluation of their anti-cardiac fibrosis activity. Arch Pharm (Weinheim). 2024 Aug;357(8):e2400131. DOI:10.1002/ardp.202400131 |
| | ALK5-IN-82 Preparation Products And Raw materials |
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