| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PROTAC CDK2 Degrader-1
CAS:3024971-78-3
Package:50mg;10mg
|
|
| | PROTAC CDK2 Degrader-1 Basic information |
| Product Name: | PROTAC CDK2 Degrader-1 | | Synonyms: | PROTAC CDK2 Degrader-1;1-(1-methyl-6-(1-((1-((4-((4-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-indazol-3-yl)dihydropyr;1-(1-methyl-6-(1-((1-((4-((4-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)piperidin-1-yl)sulfonyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione | | CAS: | 3024971-78-3 | | MF: | C38H46F6N12O4S | | MW: | 880.91 | | EINECS: | | | Product Categories: | | | Mol File: | 3024971-78-3.mol |  |
| | PROTAC CDK2 Degrader-1 Chemical Properties |
| density | 1.60±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 12.03±0.20(predicted) |
| | PROTAC CDK2 Degrader-1 Usage And Synthesis |
| Uses | PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC50 of 100-500 nM[1]. | | References | [1] Yu Z, et al., Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway. WO2024102849 |
| | PROTAC CDK2 Degrader-1 Preparation Products And Raw materials |
|