VEGFR-2-IN-52

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VEGFR-2-IN-52 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
VEGFR-2-IN-52 Basic information
Product Name:VEGFR-2-IN-52
Synonyms:VEGFR-2-IN-52;3-Thiophenecarboxamide, 4-(4-chlorophenyl)-2-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-
CAS:3046428-94-5
MF:C20H25ClN4O2S
MW:420.96
EINECS:
Product Categories:
Mol File:3046428-94-5.mol
VEGFR-2-IN-52 Structure
VEGFR-2-IN-52 Chemical Properties
Boiling point 552.5±50.0 °C(predicted)
density 1.307±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.51±0.46(predicted)
Safety Information
MSDS Information
VEGFR-2-IN-52 Usage And Synthesis
UsesVEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS[1].
References[1] Li T, et al. Discovery of novel thiophene-3-carboxamide derivatives as potential VEGFR-2 inhibitors with anti-angiogenic properties. Bioorg Chem. 2024 Jun;147:107358. DOI:10.1016/j.bioorg.2024.107358
VEGFR-2-IN-52 Preparation Products And Raw materials
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